Sorry you're feeling this way. I've never been on Azactam so I too, can't say about that one. I also haven't experienced those effects with being on Tobramycin. HOWEVER the Prednisone is a different story. I've had my share of side effects with Prednisone from feeling shaky, eating out of control and never really satisfying my hunger, to really giddy, to sad. The most recent time I was on it was last year, and at work out of no where I burst into tears <img src="i/expressions/face-icon-small-sad.gif" border="0"> Not cool, especially when working with patients. I'd have to say the Prednisone side effects you are having are something I too am familiar with. Sorry you're feeling this way, and I hope everything gets better very soon! <img src="i/expressions/face-icon-small-smile.gif" border="0">