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Kidney Failure
- Thread starter leothelioness26
- Start date
I have always known, well i have know from the time that i knew the importance of peak and through levels for Tobra
Most of the time they were ok, but in the last years i've had it they had to change to a different dose because the levels were too high and there was a bigger risk for kidney failure.
I've had lots and lots of Tobra and with the big kidney test i had for my transplant accessment i found out that they still worked for 80%
After my transplant i found out that my transplant meds are actually much stronger on my kidneys. At one point, 3 months post tx, they had gone down to 32%... Now i'm back to 57%
Most of the time they were ok, but in the last years i've had it they had to change to a different dose because the levels were too high and there was a bigger risk for kidney failure.
I've had lots and lots of Tobra and with the big kidney test i had for my transplant accessment i found out that they still worked for 80%
After my transplant i found out that my transplant meds are actually much stronger on my kidneys. At one point, 3 months post tx, they had gone down to 32%... Now i'm back to 57%
I have always known, well i have know from the time that i knew the importance of peak and through levels for Tobra
Most of the time they were ok, but in the last years i've had it they had to change to a different dose because the levels were too high and there was a bigger risk for kidney failure.
I've had lots and lots of Tobra and with the big kidney test i had for my transplant accessment i found out that they still worked for 80%
After my transplant i found out that my transplant meds are actually much stronger on my kidneys. At one point, 3 months post tx, they had gone down to 32%... Now i'm back to 57%
Most of the time they were ok, but in the last years i've had it they had to change to a different dose because the levels were too high and there was a bigger risk for kidney failure.
I've had lots and lots of Tobra and with the big kidney test i had for my transplant accessment i found out that they still worked for 80%
After my transplant i found out that my transplant meds are actually much stronger on my kidneys. At one point, 3 months post tx, they had gone down to 32%... Now i'm back to 57%
I have always known, well i have know from the time that i knew the importance of peak and through levels for Tobra
Most of the time they were ok, but in the last years i've had it they had to change to a different dose because the levels were too high and there was a bigger risk for kidney failure.
I've had lots and lots of Tobra and with the big kidney test i had for my transplant accessment i found out that they still worked for 80%
After my transplant i found out that my transplant meds are actually much stronger on my kidneys. At one point, 3 months post tx, they had gone down to 32%... Now i'm back to 57%
Most of the time they were ok, but in the last years i've had it they had to change to a different dose because the levels were too high and there was a bigger risk for kidney failure.
I've had lots and lots of Tobra and with the big kidney test i had for my transplant accessment i found out that they still worked for 80%
After my transplant i found out that my transplant meds are actually much stronger on my kidneys. At one point, 3 months post tx, they had gone down to 32%... Now i'm back to 57%
I have always known, well i have know from the time that i knew the importance of peak and through levels for Tobra
Most of the time they were ok, but in the last years i've had it they had to change to a different dose because the levels were too high and there was a bigger risk for kidney failure.
I've had lots and lots of Tobra and with the big kidney test i had for my transplant accessment i found out that they still worked for 80%
After my transplant i found out that my transplant meds are actually much stronger on my kidneys. At one point, 3 months post tx, they had gone down to 32%... Now i'm back to 57%
Most of the time they were ok, but in the last years i've had it they had to change to a different dose because the levels were too high and there was a bigger risk for kidney failure.
I've had lots and lots of Tobra and with the big kidney test i had for my transplant accessment i found out that they still worked for 80%
After my transplant i found out that my transplant meds are actually much stronger on my kidneys. At one point, 3 months post tx, they had gone down to 32%... Now i'm back to 57%
I have always known, well i have know from the time that i knew the importance of peak and through levels for Tobra
Most of the time they were ok, but in the last years i've had it they had to change to a different dose because the levels were too high and there was a bigger risk for kidney failure.
I've had lots and lots of Tobra and with the big kidney test i had for my transplant accessment i found out that they still worked for 80%
After my transplant i found out that my transplant meds are actually much stronger on my kidneys. At one point, 3 months post tx, they had gone down to 32%... Now i'm back to 57%
Most of the time they were ok, but in the last years i've had it they had to change to a different dose because the levels were too high and there was a bigger risk for kidney failure.
I've had lots and lots of Tobra and with the big kidney test i had for my transplant accessment i found out that they still worked for 80%
After my transplant i found out that my transplant meds are actually much stronger on my kidneys. At one point, 3 months post tx, they had gone down to 32%... Now i'm back to 57%
lightNlife
New member
I had kidney failure because of antibiotics about 8 years ago. My doctor had always told me about the nephrotoxicity (kidney toxicity) of the antibiotics, and the importance to drink plenty of water to flush it out of my system. Generally, the information provided to patients by their home healthcare staff, contains information about the drugs you're on, their side effects, and stuff like that. Many people don't read through that stuff, and they are surprised when they find out about some of the side effects later. It's a good idea to always familiarize yourself with the details of your medication, whether that means looking it up online (you can check out my "Medicine Cabinet" section of my Understanding Cystic Fibrosis Blog, for starters, or asking your doctor about it.
A tobramycin trough, is a blood test that involves drawing blood during the half hour before which the next dose is to be administered. If your results show that the concentration of the drug is <2 µg/mL, then you are in the safe zone. Levels of >2 µg/mL, indicate toxicity. The prescribing doctor and pharmacy are alerted, and your next dose is either delayed, or the concentration of your doses are reformulated.
A tobramycin peak, is another round of bloodwork drawn between 60 and 90 minutes after you have infused the medication. If the concentration is 4-10 µg/mL, nothing needs to be changed. If it's >12 µg/mL, again, the doctor will have you wait with your next dose, or will have the pharmacy reformulate the concentration.
Another thing the doctor might do if your kidneys are in peril, is to switch you to a low protein diet. Proteins are particularly tough for the kidneys to process, so removing or limiting it in the diet gives the kidneys a chance to rest a bit, and possibly regain function. Regaining function is entirely within the realm of possibility, especially if the doctor and patient are diligent to keep an eye on the symptoms of possible renal failure at its earliest signs. Drink plenty of water (more than you think you need) when on antibiotics. If you notice that your urine is staring to darken or smell like your medication, (this happens frequently with ceftazadime, which smells like cat urine) let your doctor know. Also be sure to let your doctor know if, during any time during your course of antibiotic treatment, you experience pain in the middle to lower portion of your back. A dull ache in that area may be indicative of kidney dysfunction.
For people who have exhibited kidney problems in response to tobra before, and you happen to be in the hospital, doctors will most likely start you on a very low dose, and have lots of labs drawn. Your dosage concentration will be ramped up with each new administration of the med until they find a safe and tolerable range for you. In my case, Tobra is one of the few meds I can tolerate, so my doc knows exactly which dose to start me at each time.
In addition to monitoring peak and trough concentrations, many CF centers are now implementing hearing screening exams. The ototoxicity (ear damaging) effect of tobra has been well established; the same was true of gentamycin, which is no longer in wide usage for that very reason.
A tobramycin trough, is a blood test that involves drawing blood during the half hour before which the next dose is to be administered. If your results show that the concentration of the drug is <2 µg/mL, then you are in the safe zone. Levels of >2 µg/mL, indicate toxicity. The prescribing doctor and pharmacy are alerted, and your next dose is either delayed, or the concentration of your doses are reformulated.
A tobramycin peak, is another round of bloodwork drawn between 60 and 90 minutes after you have infused the medication. If the concentration is 4-10 µg/mL, nothing needs to be changed. If it's >12 µg/mL, again, the doctor will have you wait with your next dose, or will have the pharmacy reformulate the concentration.
Another thing the doctor might do if your kidneys are in peril, is to switch you to a low protein diet. Proteins are particularly tough for the kidneys to process, so removing or limiting it in the diet gives the kidneys a chance to rest a bit, and possibly regain function. Regaining function is entirely within the realm of possibility, especially if the doctor and patient are diligent to keep an eye on the symptoms of possible renal failure at its earliest signs. Drink plenty of water (more than you think you need) when on antibiotics. If you notice that your urine is staring to darken or smell like your medication, (this happens frequently with ceftazadime, which smells like cat urine) let your doctor know. Also be sure to let your doctor know if, during any time during your course of antibiotic treatment, you experience pain in the middle to lower portion of your back. A dull ache in that area may be indicative of kidney dysfunction.
For people who have exhibited kidney problems in response to tobra before, and you happen to be in the hospital, doctors will most likely start you on a very low dose, and have lots of labs drawn. Your dosage concentration will be ramped up with each new administration of the med until they find a safe and tolerable range for you. In my case, Tobra is one of the few meds I can tolerate, so my doc knows exactly which dose to start me at each time.
In addition to monitoring peak and trough concentrations, many CF centers are now implementing hearing screening exams. The ototoxicity (ear damaging) effect of tobra has been well established; the same was true of gentamycin, which is no longer in wide usage for that very reason.
lightNlife
New member
I had kidney failure because of antibiotics about 8 years ago. My doctor had always told me about the nephrotoxicity (kidney toxicity) of the antibiotics, and the importance to drink plenty of water to flush it out of my system. Generally, the information provided to patients by their home healthcare staff, contains information about the drugs you're on, their side effects, and stuff like that. Many people don't read through that stuff, and they are surprised when they find out about some of the side effects later. It's a good idea to always familiarize yourself with the details of your medication, whether that means looking it up online (you can check out my "Medicine Cabinet" section of my Understanding Cystic Fibrosis Blog, for starters, or asking your doctor about it.
A tobramycin trough, is a blood test that involves drawing blood during the half hour before which the next dose is to be administered. If your results show that the concentration of the drug is <2 µg/mL, then you are in the safe zone. Levels of >2 µg/mL, indicate toxicity. The prescribing doctor and pharmacy are alerted, and your next dose is either delayed, or the concentration of your doses are reformulated.
A tobramycin peak, is another round of bloodwork drawn between 60 and 90 minutes after you have infused the medication. If the concentration is 4-10 µg/mL, nothing needs to be changed. If it's >12 µg/mL, again, the doctor will have you wait with your next dose, or will have the pharmacy reformulate the concentration.
Another thing the doctor might do if your kidneys are in peril, is to switch you to a low protein diet. Proteins are particularly tough for the kidneys to process, so removing or limiting it in the diet gives the kidneys a chance to rest a bit, and possibly regain function. Regaining function is entirely within the realm of possibility, especially if the doctor and patient are diligent to keep an eye on the symptoms of possible renal failure at its earliest signs. Drink plenty of water (more than you think you need) when on antibiotics. If you notice that your urine is staring to darken or smell like your medication, (this happens frequently with ceftazadime, which smells like cat urine) let your doctor know. Also be sure to let your doctor know if, during any time during your course of antibiotic treatment, you experience pain in the middle to lower portion of your back. A dull ache in that area may be indicative of kidney dysfunction.
For people who have exhibited kidney problems in response to tobra before, and you happen to be in the hospital, doctors will most likely start you on a very low dose, and have lots of labs drawn. Your dosage concentration will be ramped up with each new administration of the med until they find a safe and tolerable range for you. In my case, Tobra is one of the few meds I can tolerate, so my doc knows exactly which dose to start me at each time.
In addition to monitoring peak and trough concentrations, many CF centers are now implementing hearing screening exams. The ototoxicity (ear damaging) effect of tobra has been well established; the same was true of gentamycin, which is no longer in wide usage for that very reason.
A tobramycin trough, is a blood test that involves drawing blood during the half hour before which the next dose is to be administered. If your results show that the concentration of the drug is <2 µg/mL, then you are in the safe zone. Levels of >2 µg/mL, indicate toxicity. The prescribing doctor and pharmacy are alerted, and your next dose is either delayed, or the concentration of your doses are reformulated.
A tobramycin peak, is another round of bloodwork drawn between 60 and 90 minutes after you have infused the medication. If the concentration is 4-10 µg/mL, nothing needs to be changed. If it's >12 µg/mL, again, the doctor will have you wait with your next dose, or will have the pharmacy reformulate the concentration.
Another thing the doctor might do if your kidneys are in peril, is to switch you to a low protein diet. Proteins are particularly tough for the kidneys to process, so removing or limiting it in the diet gives the kidneys a chance to rest a bit, and possibly regain function. Regaining function is entirely within the realm of possibility, especially if the doctor and patient are diligent to keep an eye on the symptoms of possible renal failure at its earliest signs. Drink plenty of water (more than you think you need) when on antibiotics. If you notice that your urine is staring to darken or smell like your medication, (this happens frequently with ceftazadime, which smells like cat urine) let your doctor know. Also be sure to let your doctor know if, during any time during your course of antibiotic treatment, you experience pain in the middle to lower portion of your back. A dull ache in that area may be indicative of kidney dysfunction.
For people who have exhibited kidney problems in response to tobra before, and you happen to be in the hospital, doctors will most likely start you on a very low dose, and have lots of labs drawn. Your dosage concentration will be ramped up with each new administration of the med until they find a safe and tolerable range for you. In my case, Tobra is one of the few meds I can tolerate, so my doc knows exactly which dose to start me at each time.
In addition to monitoring peak and trough concentrations, many CF centers are now implementing hearing screening exams. The ototoxicity (ear damaging) effect of tobra has been well established; the same was true of gentamycin, which is no longer in wide usage for that very reason.
lightNlife
New member
I had kidney failure because of antibiotics about 8 years ago. My doctor had always told me about the nephrotoxicity (kidney toxicity) of the antibiotics, and the importance to drink plenty of water to flush it out of my system. Generally, the information provided to patients by their home healthcare staff, contains information about the drugs you're on, their side effects, and stuff like that. Many people don't read through that stuff, and they are surprised when they find out about some of the side effects later. It's a good idea to always familiarize yourself with the details of your medication, whether that means looking it up online (you can check out my "Medicine Cabinet" section of my Understanding Cystic Fibrosis Blog, for starters, or asking your doctor about it.
A tobramycin trough, is a blood test that involves drawing blood during the half hour before which the next dose is to be administered. If your results show that the concentration of the drug is <2 µg/mL, then you are in the safe zone. Levels of >2 µg/mL, indicate toxicity. The prescribing doctor and pharmacy are alerted, and your next dose is either delayed, or the concentration of your doses are reformulated.
A tobramycin peak, is another round of bloodwork drawn between 60 and 90 minutes after you have infused the medication. If the concentration is 4-10 µg/mL, nothing needs to be changed. If it's >12 µg/mL, again, the doctor will have you wait with your next dose, or will have the pharmacy reformulate the concentration.
Another thing the doctor might do if your kidneys are in peril, is to switch you to a low protein diet. Proteins are particularly tough for the kidneys to process, so removing or limiting it in the diet gives the kidneys a chance to rest a bit, and possibly regain function. Regaining function is entirely within the realm of possibility, especially if the doctor and patient are diligent to keep an eye on the symptoms of possible renal failure at its earliest signs. Drink plenty of water (more than you think you need) when on antibiotics. If you notice that your urine is staring to darken or smell like your medication, (this happens frequently with ceftazadime, which smells like cat urine) let your doctor know. Also be sure to let your doctor know if, during any time during your course of antibiotic treatment, you experience pain in the middle to lower portion of your back. A dull ache in that area may be indicative of kidney dysfunction.
For people who have exhibited kidney problems in response to tobra before, and you happen to be in the hospital, doctors will most likely start you on a very low dose, and have lots of labs drawn. Your dosage concentration will be ramped up with each new administration of the med until they find a safe and tolerable range for you. In my case, Tobra is one of the few meds I can tolerate, so my doc knows exactly which dose to start me at each time.
In addition to monitoring peak and trough concentrations, many CF centers are now implementing hearing screening exams. The ototoxicity (ear damaging) effect of tobra has been well established; the same was true of gentamycin, which is no longer in wide usage for that very reason.
A tobramycin trough, is a blood test that involves drawing blood during the half hour before which the next dose is to be administered. If your results show that the concentration of the drug is <2 µg/mL, then you are in the safe zone. Levels of >2 µg/mL, indicate toxicity. The prescribing doctor and pharmacy are alerted, and your next dose is either delayed, or the concentration of your doses are reformulated.
A tobramycin peak, is another round of bloodwork drawn between 60 and 90 minutes after you have infused the medication. If the concentration is 4-10 µg/mL, nothing needs to be changed. If it's >12 µg/mL, again, the doctor will have you wait with your next dose, or will have the pharmacy reformulate the concentration.
Another thing the doctor might do if your kidneys are in peril, is to switch you to a low protein diet. Proteins are particularly tough for the kidneys to process, so removing or limiting it in the diet gives the kidneys a chance to rest a bit, and possibly regain function. Regaining function is entirely within the realm of possibility, especially if the doctor and patient are diligent to keep an eye on the symptoms of possible renal failure at its earliest signs. Drink plenty of water (more than you think you need) when on antibiotics. If you notice that your urine is staring to darken or smell like your medication, (this happens frequently with ceftazadime, which smells like cat urine) let your doctor know. Also be sure to let your doctor know if, during any time during your course of antibiotic treatment, you experience pain in the middle to lower portion of your back. A dull ache in that area may be indicative of kidney dysfunction.
For people who have exhibited kidney problems in response to tobra before, and you happen to be in the hospital, doctors will most likely start you on a very low dose, and have lots of labs drawn. Your dosage concentration will be ramped up with each new administration of the med until they find a safe and tolerable range for you. In my case, Tobra is one of the few meds I can tolerate, so my doc knows exactly which dose to start me at each time.
In addition to monitoring peak and trough concentrations, many CF centers are now implementing hearing screening exams. The ototoxicity (ear damaging) effect of tobra has been well established; the same was true of gentamycin, which is no longer in wide usage for that very reason.
lightNlife
New member
I had kidney failure because of antibiotics about 8 years ago. My doctor had always told me about the nephrotoxicity (kidney toxicity) of the antibiotics, and the importance to drink plenty of water to flush it out of my system. Generally, the information provided to patients by their home healthcare staff, contains information about the drugs you're on, their side effects, and stuff like that. Many people don't read through that stuff, and they are surprised when they find out about some of the side effects later. It's a good idea to always familiarize yourself with the details of your medication, whether that means looking it up online (you can check out my "Medicine Cabinet" section of my Understanding Cystic Fibrosis Blog, for starters, or asking your doctor about it.
A tobramycin trough, is a blood test that involves drawing blood during the half hour before which the next dose is to be administered. If your results show that the concentration of the drug is <2 µg/mL, then you are in the safe zone. Levels of >2 µg/mL, indicate toxicity. The prescribing doctor and pharmacy are alerted, and your next dose is either delayed, or the concentration of your doses are reformulated.
A tobramycin peak, is another round of bloodwork drawn between 60 and 90 minutes after you have infused the medication. If the concentration is 4-10 µg/mL, nothing needs to be changed. If it's >12 µg/mL, again, the doctor will have you wait with your next dose, or will have the pharmacy reformulate the concentration.
Another thing the doctor might do if your kidneys are in peril, is to switch you to a low protein diet. Proteins are particularly tough for the kidneys to process, so removing or limiting it in the diet gives the kidneys a chance to rest a bit, and possibly regain function. Regaining function is entirely within the realm of possibility, especially if the doctor and patient are diligent to keep an eye on the symptoms of possible renal failure at its earliest signs. Drink plenty of water (more than you think you need) when on antibiotics. If you notice that your urine is staring to darken or smell like your medication, (this happens frequently with ceftazadime, which smells like cat urine) let your doctor know. Also be sure to let your doctor know if, during any time during your course of antibiotic treatment, you experience pain in the middle to lower portion of your back. A dull ache in that area may be indicative of kidney dysfunction.
For people who have exhibited kidney problems in response to tobra before, and you happen to be in the hospital, doctors will most likely start you on a very low dose, and have lots of labs drawn. Your dosage concentration will be ramped up with each new administration of the med until they find a safe and tolerable range for you. In my case, Tobra is one of the few meds I can tolerate, so my doc knows exactly which dose to start me at each time.
In addition to monitoring peak and trough concentrations, many CF centers are now implementing hearing screening exams. The ototoxicity (ear damaging) effect of tobra has been well established; the same was true of gentamycin, which is no longer in wide usage for that very reason.
A tobramycin trough, is a blood test that involves drawing blood during the half hour before which the next dose is to be administered. If your results show that the concentration of the drug is <2 µg/mL, then you are in the safe zone. Levels of >2 µg/mL, indicate toxicity. The prescribing doctor and pharmacy are alerted, and your next dose is either delayed, or the concentration of your doses are reformulated.
A tobramycin peak, is another round of bloodwork drawn between 60 and 90 minutes after you have infused the medication. If the concentration is 4-10 µg/mL, nothing needs to be changed. If it's >12 µg/mL, again, the doctor will have you wait with your next dose, or will have the pharmacy reformulate the concentration.
Another thing the doctor might do if your kidneys are in peril, is to switch you to a low protein diet. Proteins are particularly tough for the kidneys to process, so removing or limiting it in the diet gives the kidneys a chance to rest a bit, and possibly regain function. Regaining function is entirely within the realm of possibility, especially if the doctor and patient are diligent to keep an eye on the symptoms of possible renal failure at its earliest signs. Drink plenty of water (more than you think you need) when on antibiotics. If you notice that your urine is staring to darken or smell like your medication, (this happens frequently with ceftazadime, which smells like cat urine) let your doctor know. Also be sure to let your doctor know if, during any time during your course of antibiotic treatment, you experience pain in the middle to lower portion of your back. A dull ache in that area may be indicative of kidney dysfunction.
For people who have exhibited kidney problems in response to tobra before, and you happen to be in the hospital, doctors will most likely start you on a very low dose, and have lots of labs drawn. Your dosage concentration will be ramped up with each new administration of the med until they find a safe and tolerable range for you. In my case, Tobra is one of the few meds I can tolerate, so my doc knows exactly which dose to start me at each time.
In addition to monitoring peak and trough concentrations, many CF centers are now implementing hearing screening exams. The ototoxicity (ear damaging) effect of tobra has been well established; the same was true of gentamycin, which is no longer in wide usage for that very reason.
lightNlife
New member
I had kidney failure because of antibiotics about 8 years ago. My doctor had always told me about the nephrotoxicity (kidney toxicity) of the antibiotics, and the importance to drink plenty of water to flush it out of my system. Generally, the information provided to patients by their home healthcare staff, contains information about the drugs you're on, their side effects, and stuff like that. Many people don't read through that stuff, and they are surprised when they find out about some of the side effects later. It's a good idea to always familiarize yourself with the details of your medication, whether that means looking it up online (you can check out my "Medicine Cabinet" section of my Understanding Cystic Fibrosis Blog, for starters, or asking your doctor about it.
A tobramycin trough, is a blood test that involves drawing blood during the half hour before which the next dose is to be administered. If your results show that the concentration of the drug is <2 µg/mL, then you are in the safe zone. Levels of >2 µg/mL, indicate toxicity. The prescribing doctor and pharmacy are alerted, and your next dose is either delayed, or the concentration of your doses are reformulated.
A tobramycin peak, is another round of bloodwork drawn between 60 and 90 minutes after you have infused the medication. If the concentration is 4-10 µg/mL, nothing needs to be changed. If it's >12 µg/mL, again, the doctor will have you wait with your next dose, or will have the pharmacy reformulate the concentration.
Another thing the doctor might do if your kidneys are in peril, is to switch you to a low protein diet. Proteins are particularly tough for the kidneys to process, so removing or limiting it in the diet gives the kidneys a chance to rest a bit, and possibly regain function. Regaining function is entirely within the realm of possibility, especially if the doctor and patient are diligent to keep an eye on the symptoms of possible renal failure at its earliest signs. Drink plenty of water (more than you think you need) when on antibiotics. If you notice that your urine is staring to darken or smell like your medication, (this happens frequently with ceftazadime, which smells like cat urine) let your doctor know. Also be sure to let your doctor know if, during any time during your course of antibiotic treatment, you experience pain in the middle to lower portion of your back. A dull ache in that area may be indicative of kidney dysfunction.
For people who have exhibited kidney problems in response to tobra before, and you happen to be in the hospital, doctors will most likely start you on a very low dose, and have lots of labs drawn. Your dosage concentration will be ramped up with each new administration of the med until they find a safe and tolerable range for you. In my case, Tobra is one of the few meds I can tolerate, so my doc knows exactly which dose to start me at each time.
In addition to monitoring peak and trough concentrations, many CF centers are now implementing hearing screening exams. The ototoxicity (ear damaging) effect of tobra has been well established; the same was true of gentamycin, which is no longer in wide usage for that very reason.
A tobramycin trough, is a blood test that involves drawing blood during the half hour before which the next dose is to be administered. If your results show that the concentration of the drug is <2 µg/mL, then you are in the safe zone. Levels of >2 µg/mL, indicate toxicity. The prescribing doctor and pharmacy are alerted, and your next dose is either delayed, or the concentration of your doses are reformulated.
A tobramycin peak, is another round of bloodwork drawn between 60 and 90 minutes after you have infused the medication. If the concentration is 4-10 µg/mL, nothing needs to be changed. If it's >12 µg/mL, again, the doctor will have you wait with your next dose, or will have the pharmacy reformulate the concentration.
Another thing the doctor might do if your kidneys are in peril, is to switch you to a low protein diet. Proteins are particularly tough for the kidneys to process, so removing or limiting it in the diet gives the kidneys a chance to rest a bit, and possibly regain function. Regaining function is entirely within the realm of possibility, especially if the doctor and patient are diligent to keep an eye on the symptoms of possible renal failure at its earliest signs. Drink plenty of water (more than you think you need) when on antibiotics. If you notice that your urine is staring to darken or smell like your medication, (this happens frequently with ceftazadime, which smells like cat urine) let your doctor know. Also be sure to let your doctor know if, during any time during your course of antibiotic treatment, you experience pain in the middle to lower portion of your back. A dull ache in that area may be indicative of kidney dysfunction.
For people who have exhibited kidney problems in response to tobra before, and you happen to be in the hospital, doctors will most likely start you on a very low dose, and have lots of labs drawn. Your dosage concentration will be ramped up with each new administration of the med until they find a safe and tolerable range for you. In my case, Tobra is one of the few meds I can tolerate, so my doc knows exactly which dose to start me at each time.
In addition to monitoring peak and trough concentrations, many CF centers are now implementing hearing screening exams. The ototoxicity (ear damaging) effect of tobra has been well established; the same was true of gentamycin, which is no longer in wide usage for that very reason.
**Raises hand**jumps up and down**And screams at the top of my lungs** (well as best i can,lol) I went into full renal failure due to tobramycin .. reason being, i was vomiting, having diarrhea and not on IV fluids (insanely enough) I was having peaks and troughs done, but when they reached the level that was needed they didn't check any more ( supposedly that protocol was going to be reviewed after my incident) I didn't know who i was or where i was for 3 days.. I had to have a porta cath placed, because my port was a peds port and to small for the dialysis i need.. I had to have several dialysis sessions done.. After the port was removed, i ended up w/ a DVT (blood clot) and had to be on blood thinner for 6 mos. I do believe i signed off on these things as a possibility... So my 1 wk. tune up turned into a 6 wk. nightmare and oh yes it's well over 3 yrs and i still have ringing in my ears... BTW guys, whenever on any abx , drink like crazy, and if on IV's ask for IV fluids, especially if you know you can't or wont drink... <img src="i/expressions/heart.gif" border="0"> joni
**Raises hand**jumps up and down**And screams at the top of my lungs** (well as best i can,lol) I went into full renal failure due to tobramycin .. reason being, i was vomiting, having diarrhea and not on IV fluids (insanely enough) I was having peaks and troughs done, but when they reached the level that was needed they didn't check any more ( supposedly that protocol was going to be reviewed after my incident) I didn't know who i was or where i was for 3 days.. I had to have a porta cath placed, because my port was a peds port and to small for the dialysis i need.. I had to have several dialysis sessions done.. After the port was removed, i ended up w/ a DVT (blood clot) and had to be on blood thinner for 6 mos. I do believe i signed off on these things as a possibility... So my 1 wk. tune up turned into a 6 wk. nightmare and oh yes it's well over 3 yrs and i still have ringing in my ears... BTW guys, whenever on any abx , drink like crazy, and if on IV's ask for IV fluids, especially if you know you can't or wont drink... <img src="i/expressions/heart.gif" border="0"> joni
**Raises hand**jumps up and down**And screams at the top of my lungs** (well as best i can,lol) I went into full renal failure due to tobramycin .. reason being, i was vomiting, having diarrhea and not on IV fluids (insanely enough) I was having peaks and troughs done, but when they reached the level that was needed they didn't check any more ( supposedly that protocol was going to be reviewed after my incident) I didn't know who i was or where i was for 3 days.. I had to have a porta cath placed, because my port was a peds port and to small for the dialysis i need.. I had to have several dialysis sessions done.. After the port was removed, i ended up w/ a DVT (blood clot) and had to be on blood thinner for 6 mos. I do believe i signed off on these things as a possibility... So my 1 wk. tune up turned into a 6 wk. nightmare and oh yes it's well over 3 yrs and i still have ringing in my ears... BTW guys, whenever on any abx , drink like crazy, and if on IV's ask for IV fluids, especially if you know you can't or wont drink... <img src="i/expressions/heart.gif" border="0"> joni
**Raises hand**jumps up and down**And screams at the top of my lungs** (well as best i can,lol) I went into full renal failure due to tobramycin .. reason being, i was vomiting, having diarrhea and not on IV fluids (insanely enough) I was having peaks and troughs done, but when they reached the level that was needed they didn't check any more ( supposedly that protocol was going to be reviewed after my incident) I didn't know who i was or where i was for 3 days.. I had to have a porta cath placed, because my port was a peds port and to small for the dialysis i need.. I had to have several dialysis sessions done.. After the port was removed, i ended up w/ a DVT (blood clot) and had to be on blood thinner for 6 mos. I do believe i signed off on these things as a possibility... So my 1 wk. tune up turned into a 6 wk. nightmare and oh yes it's well over 3 yrs and i still have ringing in my ears... BTW guys, whenever on any abx , drink like crazy, and if on IV's ask for IV fluids, especially if you know you can't or wont drink... <img src="i/expressions/heart.gif" border="0"> joni
**Raises hand**jumps up and down**And screams at the top of my lungs** (well as best i can,lol) I went into full renal failure due to tobramycin .. reason being, i was vomiting, having diarrhea and not on IV fluids (insanely enough) I was having peaks and troughs done, but when they reached the level that was needed they didn't check any more ( supposedly that protocol was going to be reviewed after my incident) I didn't know who i was or where i was for 3 days.. I had to have a porta cath placed, because my port was a peds port and to small for the dialysis i need.. I had to have several dialysis sessions done.. After the port was removed, i ended up w/ a DVT (blood clot) and had to be on blood thinner for 6 mos. I do believe i signed off on these things as a possibility... So my 1 wk. tune up turned into a 6 wk. nightmare and oh yes it's well over 3 yrs and i still have ringing in my ears... BTW guys, whenever on any abx , drink like crazy, and if on IV's ask for IV fluids, especially if you know you can't or wont drink... <img src="i/expressions/heart.gif" border="0"> joni