Newborns tongues automatically push things out for about 3 months or so. Sort of a genetic safety measure. We started giving DS enzymes at 1 week old -- we started off using a tongue depresser, slid in and out easily; however, a couple of times we irritated the roof of his mouth, so we switched to as flat of a baby spoon as we could find. Also, baby food bananas worked much better than applesauce -- was stickier, so the enzymes stuck to them and stayed in the mouth.
Also depends upon the type of enzymes - pancreacarb, which is what we started with -- THOUSANDS of tiny microbeads, which I'd find in his hair, on me, on his clothing, bedding, the floor -- and if they got on skin, they'd irritate. We'd started switching to an oral syringe with bananas, but then the doctor switched him to Pancrease mt4s, bigger beads that wouldn't fit in a syringe, but easier to keep track of.
Basically it just takes practice. We'd slip in the enzymes and follow very quickly with the bottle.