Our nutritionist gave us the maximum amount of enzymes that our ds can have (not sure what they base it on...maybe weight/size). Anyway, he can have a max of 5-6 Creon 10 per meal. We usually give him 4. He was needing about 1 Creon 10 per 10 grams of fat he ate (to keep his stools non greasy) but now he needs 1 Creon 10 for about every 8 grams of fat. We try to get him a minimum of 20 grams of fat and 15 grams of protein per meal.