I've been on it for about, let's see- 15 years or so now (I was in the study too <img src="i/expressions/face-icon-small-wink.gif" border="0"> ), and I did have a couple of bouts of streaking during the study. If I do have streaking/bleeding, that is one of the things I go off of for 24 hours, along with my vest and HS. That is really the only thing I can think of at the moment.
I can tell too if I miss a dose (I am on it twice a day). I think it's great! <img src="i/expressions/face-icon-small-smile.gif" border="0"> I've also been known to snort a few puffs of a dose in my nose too, or inhale through my mouth and out my nose during my pulmozyme neb- sometimes it helps if I'm chronically stuffy, lol. (Btw, I'm doing mine now too <img src="i/expressions/face-icon-small-wink.gif" border="0"> )