I know a lot of CFers use Prednisone, so hopefully someone can answer this for me. I just finished up an 8 day course this past Wednesday. I had a reaction to something and they put me on prednisone for it (that's another story-I've never had an allergic reaction to something). I have only been on it once before so I'm not all that familiar with all the side effects. Aside from the major ones, like weight gain and insomnia, have any of you experienced muscle soreness? My shoulders, arms, shoulder blades, ribs, side and my neck are terribly sore. It feels like if you exercised after not working for a long time and the next day you are sore, only worse. My last dose was on Wednesday so I'm not sure how long it stays in your system. I was going to have my husband use the percussor on my back tonight, but it hurt so bad so I couldn't do my back. Just wondered if anybody else has experienced this, and if so, how long did it last? Thanks!