Spontaneous Mutation

my65roses4me · Jun 19, 2007

I find this post so interesting because I have never heard of spontaneous mutations. How scary is that!!!
When are they created? Is like the other genes, are we born with them and they show up later? Or are they created later in life?
This brings up so many questions. What about the CFers that are thinking about having kids? We have our spouses checked for mutations and it comes back negative, does that mean it can show up later?

Vicky,
I am just curious about something you said. Why would your hubby lose his job if he is tested positive? Call me air headed but I dont get it. LOL

my65roses4me · Jun 19, 2007

I find this post so interesting because I have never heard of spontaneous mutations. How scary is that!!!
When are they created? Is like the other genes, are we born with them and they show up later? Or are they created later in life?
This brings up so many questions. What about the CFers that are thinking about having kids? We have our spouses checked for mutations and it comes back negative, does that mean it can show up later?

Vicky,
I am just curious about something you said. Why would your hubby lose his job if he is tested positive? Call me air headed but I dont get it. LOL

vmhoward · Jun 19, 2007

He is in the Military, they would medically discharge him. And his dreams of being a Police Officer when he gets out of the Military would be null and Void as well.

Thanks for asking, Good question about the timing on the spontaneous mutation. Anyone know the answer to this.

okok,

since it happens in the germ cells then does it happen before conception or after?

vmhoward · Jun 19, 2007

He is in the Military, they would medically discharge him. And his dreams of being a Police Officer when he gets out of the Military would be null and Void as well.

Thanks for asking, Good question about the timing on the spontaneous mutation. Anyone know the answer to this.

okok,

since it happens in the germ cells then does it happen before conception or after?

vmhoward · Jun 19, 2007

He is in the Military, they would medically discharge him. And his dreams of being a Police Officer when he gets out of the Military would be null and Void as well.

Thanks for asking, Good question about the timing on the spontaneous mutation. Anyone know the answer to this.

okok,

since it happens in the germ cells then does it happen before conception or after?

vmhoward · Jun 19, 2007

He is in the Military, they would medically discharge him. And his dreams of being a Police Officer when he gets out of the Military would be null and Void as well.

Thanks for asking, Good question about the timing on the spontaneous mutation. Anyone know the answer to this.

okok,

since it happens in the germ cells then does it happen before conception or after?

vmhoward · Jun 19, 2007

He is in the Military, they would medically discharge him. And his dreams of being a Police Officer when he gets out of the Military would be null and Void as well.

Thanks for asking, Good question about the timing on the spontaneous mutation. Anyone know the answer to this.

okok,

since it happens in the germ cells then does it happen before conception or after?

vmhoward · Jun 19, 2007

He is in the Military, they would medically discharge him. And his dreams of being a Police Officer when he gets out of the Military would be null and Void as well.

Thanks for asking, Good question about the timing on the spontaneous mutation. Anyone know the answer to this.

okok,

since it happens in the germ cells then does it happen before conception or after?

okok · Jun 19, 2007

well i think first you should go ahead with the genetics testing on your son and see what those results are before worrying about your husband. If it is a spontaneous mutation, then it will most likely be the first of its kind, ie never heard of before. I imagine it would be pretty unlikely that a spontaneous mutation would arise that is identical to another mutation but that is also possible. Anyway if it is a mutation that is relatively common (ie compared to a completely new mutation not compared to delf508 since all mutations are rare compared to delf508) then it seems like more of a possibility that it was passed on from your husband or yourself to your son.

It seems very unlikely your husband has two mutations in the CFTR because he hasn't had any trouble concieving childern. Often, men are completely symptomless of CF, but are found to have two CFTR mutations when it turns out they are infertile or are having trouble concieving childern.

My grandfather frequently gets pneumonia and is chronically congested and he is just a carrier. He may (???, it may be other genetics too) be more susceptable to gettting pneumonia due to his carrier status. He just had a chest x-ray though and his lungs are healthy, completely healed from his last bout of pneumonia. Lung damage does not occur in him the way it occurs in people with CF. What i am trying to say is that while carriers may have some symptoms due to their mutations it isn't exactly CF.

Good luck!

okok · Jun 19, 2007

well i think first you should go ahead with the genetics testing on your son and see what those results are before worrying about your husband. If it is a spontaneous mutation, then it will most likely be the first of its kind, ie never heard of before. I imagine it would be pretty unlikely that a spontaneous mutation would arise that is identical to another mutation but that is also possible. Anyway if it is a mutation that is relatively common (ie compared to a completely new mutation not compared to delf508 since all mutations are rare compared to delf508) then it seems like more of a possibility that it was passed on from your husband or yourself to your son.

It seems very unlikely your husband has two mutations in the CFTR because he hasn't had any trouble concieving childern. Often, men are completely symptomless of CF, but are found to have two CFTR mutations when it turns out they are infertile or are having trouble concieving childern.

My grandfather frequently gets pneumonia and is chronically congested and he is just a carrier. He may (???, it may be other genetics too) be more susceptable to gettting pneumonia due to his carrier status. He just had a chest x-ray though and his lungs are healthy, completely healed from his last bout of pneumonia. Lung damage does not occur in him the way it occurs in people with CF. What i am trying to say is that while carriers may have some symptoms due to their mutations it isn't exactly CF.

Good luck!

okok · Jun 19, 2007

well i think first you should go ahead with the genetics testing on your son and see what those results are before worrying about your husband. If it is a spontaneous mutation, then it will most likely be the first of its kind, ie never heard of before. I imagine it would be pretty unlikely that a spontaneous mutation would arise that is identical to another mutation but that is also possible. Anyway if it is a mutation that is relatively common (ie compared to a completely new mutation not compared to delf508 since all mutations are rare compared to delf508) then it seems like more of a possibility that it was passed on from your husband or yourself to your son.

It seems very unlikely your husband has two mutations in the CFTR because he hasn't had any trouble concieving childern. Often, men are completely symptomless of CF, but are found to have two CFTR mutations when it turns out they are infertile or are having trouble concieving childern.

My grandfather frequently gets pneumonia and is chronically congested and he is just a carrier. He may (???, it may be other genetics too) be more susceptable to gettting pneumonia due to his carrier status. He just had a chest x-ray though and his lungs are healthy, completely healed from his last bout of pneumonia. Lung damage does not occur in him the way it occurs in people with CF. What i am trying to say is that while carriers may have some symptoms due to their mutations it isn't exactly CF.

Good luck!

okok · Jun 19, 2007

well i think first you should go ahead with the genetics testing on your son and see what those results are before worrying about your husband. If it is a spontaneous mutation, then it will most likely be the first of its kind, ie never heard of before. I imagine it would be pretty unlikely that a spontaneous mutation would arise that is identical to another mutation but that is also possible. Anyway if it is a mutation that is relatively common (ie compared to a completely new mutation not compared to delf508 since all mutations are rare compared to delf508) then it seems like more of a possibility that it was passed on from your husband or yourself to your son.

It seems very unlikely your husband has two mutations in the CFTR because he hasn't had any trouble concieving childern. Often, men are completely symptomless of CF, but are found to have two CFTR mutations when it turns out they are infertile or are having trouble concieving childern.

My grandfather frequently gets pneumonia and is chronically congested and he is just a carrier. He may (???, it may be other genetics too) be more susceptable to gettting pneumonia due to his carrier status. He just had a chest x-ray though and his lungs are healthy, completely healed from his last bout of pneumonia. Lung damage does not occur in him the way it occurs in people with CF. What i am trying to say is that while carriers may have some symptoms due to their mutations it isn't exactly CF.

Good luck!

okok · Jun 19, 2007

well i think first you should go ahead with the genetics testing on your son and see what those results are before worrying about your husband. If it is a spontaneous mutation, then it will most likely be the first of its kind, ie never heard of before. I imagine it would be pretty unlikely that a spontaneous mutation would arise that is identical to another mutation but that is also possible. Anyway if it is a mutation that is relatively common (ie compared to a completely new mutation not compared to delf508 since all mutations are rare compared to delf508) then it seems like more of a possibility that it was passed on from your husband or yourself to your son.

It seems very unlikely your husband has two mutations in the CFTR because he hasn't had any trouble concieving childern. Often, men are completely symptomless of CF, but are found to have two CFTR mutations when it turns out they are infertile or are having trouble concieving childern.

My grandfather frequently gets pneumonia and is chronically congested and he is just a carrier. He may (???, it may be other genetics too) be more susceptable to gettting pneumonia due to his carrier status. He just had a chest x-ray though and his lungs are healthy, completely healed from his last bout of pneumonia. Lung damage does not occur in him the way it occurs in people with CF. What i am trying to say is that while carriers may have some symptoms due to their mutations it isn't exactly CF.

Good luck!

okok · Jun 19, 2007

well i think first you should go ahead with the genetics testing on your son and see what those results are before worrying about your husband. If it is a spontaneous mutation, then it will most likely be the first of its kind, ie never heard of before. I imagine it would be pretty unlikely that a spontaneous mutation would arise that is identical to another mutation but that is also possible. Anyway if it is a mutation that is relatively common (ie compared to a completely new mutation not compared to delf508 since all mutations are rare compared to delf508) then it seems like more of a possibility that it was passed on from your husband or yourself to your son.

It seems very unlikely your husband has two mutations in the CFTR because he hasn't had any trouble concieving childern. Often, men are completely symptomless of CF, but are found to have two CFTR mutations when it turns out they are infertile or are having trouble concieving childern.

My grandfather frequently gets pneumonia and is chronically congested and he is just a carrier. He may (???, it may be other genetics too) be more susceptable to gettting pneumonia due to his carrier status. He just had a chest x-ray though and his lungs are healthy, completely healed from his last bout of pneumonia. Lung damage does not occur in him the way it occurs in people with CF. What i am trying to say is that while carriers may have some symptoms due to their mutations it isn't exactly CF.

Good luck!

vmhoward · Jun 19, 2007