770 approved!!!!!!!!!

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dramamama

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Kristen</b></i> This is so wonderful!!!! I thought they just approved it for G551D? I thought they were doing additional trials for the other gating mutations. I'm curious to hear from those with G551D how the insurance approval process works - will insurance start covering it right away?</end quote>

Other gating mutations are less common in CF and account for <span><1% of mutant alleles. In vitro studies using CF epithelial cell lines show that the gating mutations respond to VX-770 in a similar manner to the G551D mutation in vitro.
 
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dramamama

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Kristen</b></i> This is so wonderful!!!! I thought they just approved it for G551D? I thought they were doing additional trials for the other gating mutations. I'm curious to hear from those with G551D how the insurance approval process works - will insurance start covering it right away?</end quote>

Other gating mutations are less common in CF and account for <span><1% of mutant alleles. In vitro studies using CF epithelial cell lines show that the gating mutations respond to VX-770 in a similar manner to the G551D mutation in vitro.
 
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cfsucks

Guest
i just read it will cost 294 000 per patient a year... who covers this cost??!
 
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cfsucks

Guest
i just read it will cost 294 000 per patient a year... who covers this cost??!
 
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Kristen

New member
dramamama, I tried to quote you but I couldn't get it to work properly. Anyway, I know that about gating mutations, but I thought they were doing additional trials so that it could be approved by the FDA for other mutations. From CFF.org: "Vertex is planning clinical trials of Kalydeco in patient groups that were not evaluated in earlier Phase 3 studies of the drug, including: Children ages 2 to 5 with gating mutations, including G551D. People with other gating mutations besides G551D. People with at least one copy of the R117H mutation of CF." Regardless, I agree with you that it should work for other gating mutations, and it is super exciting! It's just my understanding that it isn't approved for other gating mutations YET.
Edited to add: I'm sorry, I misread what you initially wrote - I thought you were saying it's approved for all gating mutations. But you were just saying that it helps all gating mutations!
 
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Kristen

New member
dramamama, I tried to quote you but I couldn't get it to work properly. Anyway, I know that about gating mutations, but I thought they were doing additional trials so that it could be approved by the FDA for other mutations. From CFF.org: "Vertex is planning clinical trials of Kalydeco in patient groups that were not evaluated in earlier Phase 3 studies of the drug, including: Children ages 2 to 5 with gating mutations, including G551D. People with other gating mutations besides G551D. People with at least one copy of the R117H mutation of CF." Regardless, I agree with you that it should work for other gating mutations, and it is super exciting! It's just my understanding that it isn't approved for other gating mutations YET.
Edited to add: I'm sorry, I misread what you initially wrote - I thought you were saying it's approved for all gating mutations. But you were just saying that it helps all gating mutations!
 
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Incomudrox

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>cfsucks</b></i> i just read it will cost 294 000 per patient a year... who covers this cost??!</end quote>

Insurance companies will probably be willing to JUMP at this actually. Let us think about this a second. I stayed in the hospital last April for the normal stay.. the bill? $166,000~. If your average CFer under 18 is going 4-5 times per year for example... so if they can prevent all or some of them they are breaking even at 2 stays and saving money if they can prevent more than 3. Further more they might save if the patients are able to stop taking some medications. If they can save from ever having to pay for a tx? saving more than 1 million right there.
 
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Incomudrox

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>cfsucks</b></i> i just read it will cost 294 000 per patient a year... who covers this cost??!</end quote>

Insurance companies will probably be willing to JUMP at this actually. Let us think about this a second. I stayed in the hospital last April for the normal stay.. the bill? $166,000~. If your average CFer under 18 is going 4-5 times per year for example... so if they can prevent all or some of them they are breaking even at 2 stays and saving money if they can prevent more than 3. Further more they might save if the patients are able to stop taking some medications. If they can save from ever having to pay for a tx? saving more than 1 million right there.
 
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MCGrad2006

Guest
LOVE this!!! Saw it on my facebook at work and then national news tonight! Wonderful. Can't wait to hear what my doctor says next week when I see him. He will be over the moon! (I am not a gating mutation, but hoping to potentially get into new trials for other versions). <img src="i/expressions/face-icon-small-smile.gif" border="0"> Beyond cool!
 
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MCGrad2006

Guest
LOVE this!!! Saw it on my facebook at work and then national news tonight! Wonderful. Can't wait to hear what my doctor says next week when I see him. He will be over the moon! (I am not a gating mutation, but hoping to potentially get into new trials for other versions). <img src="i/expressions/face-icon-small-smile.gif" border="0"> Beyond cool!
 
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saveferris2009

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Incomudrox</b></i> <div class="FTQUOTE"><begin quote><i>Originally posted by: <b>cfsucks</b></i> i just read it will cost 294 000 per patient a year... who covers this cost??!</end quote> Insurance companies will probably be willing to JUMP at this actually. Let us think about this a second. I stayed in the hospital last April for the normal stay.. the bill? $166,000~. If your average CFer under 18 is going 4-5 times per year for example... so if they can prevent all or some of them they are breaking even at 2 stays and saving money if they can prevent more than 3. Further more they might save if the patients are able to stop taking some medications. If they can save from ever having to pay for a tx? saving more than 1 million right there.</end quote>

pharmacoeconomics <img src="i/expressions/face-icon-small-smile.gif" border="0"> yey!

i agree 100%
 
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saveferris2009

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Incomudrox</b></i> <div class="FTQUOTE"><begin quote><i>Originally posted by: <b>cfsucks</b></i> i just read it will cost 294 000 per patient a year... who covers this cost??!</end quote> Insurance companies will probably be willing to JUMP at this actually. Let us think about this a second. I stayed in the hospital last April for the normal stay.. the bill? $166,000~. If your average CFer under 18 is going 4-5 times per year for example... so if they can prevent all or some of them they are breaking even at 2 stays and saving money if they can prevent more than 3. Further more they might save if the patients are able to stop taking some medications. If they can save from ever having to pay for a tx? saving more than 1 million right there.</end quote>

pharmacoeconomics <img src="i/expressions/face-icon-small-smile.gif" border="0"> yey!

i agree 100%
 
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carly23

New member
What about DF508 is this included <img src="i/expressions/face-icon-small-sad.gif" border="0"> i hope so!..this is amazing news!!!i cried lol <img src="i/expressions/face-icon-small-happy.gif" border="0">
 
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carly23

New member
What about DF508 is this included <img src="i/expressions/face-icon-small-sad.gif" border="0"> i hope so!..this is amazing news!!!i cried lol <img src="i/expressions/face-icon-small-happy.gif" border="0">
 
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