The way I understand it is that Pulmozyme is an enzyme which breaks down the long proteins and DNA chains from killed infections. These proteins are left in the mucus after our immune system has attacked bacteria and killed them. Because they're long chains they thicken the mucus. Pulmozyme basically cuts the proteins into smaller pieces, effectively reducing the viscosity of the mucus.
However the enzymes need time to penetrate the mucus and take effect. That is a several hour long process and the pulmozyme dosing is set so that there is sufficient amount to work over a longer course of time - like over many hours (not minutes, like Xopenex).
I think taking pulmozyme right before HTS only allows it to barely penetrate the upper layer which you're going to get out easily! Ideally Pulmozyme is more effective if it hangs around in the lungs over a longer time penetrating the stuck and thicker mucus even deeper. Then the next morning after HTS the stuff Pulmozyme loosened over the prior day can be cleared out.
I also think that HTS thins the mucus. My understanding is that it works by creating a saltier environment. Naturally through osmosis, water is then moved to the areas the HTS penetrated to dilute the salt, in effect thinning the mucus, making it move, tickle and invoking a coughing response. There can also be coughing due to irritation of course.
Anyways, that's the rationale as it was explained to me and IMHO it makes sense. You should bring up the question of the sequencing with your doctor. ~Juliet
However the enzymes need time to penetrate the mucus and take effect. That is a several hour long process and the pulmozyme dosing is set so that there is sufficient amount to work over a longer course of time - like over many hours (not minutes, like Xopenex).
I think taking pulmozyme right before HTS only allows it to barely penetrate the upper layer which you're going to get out easily! Ideally Pulmozyme is more effective if it hangs around in the lungs over a longer time penetrating the stuck and thicker mucus even deeper. Then the next morning after HTS the stuff Pulmozyme loosened over the prior day can be cleared out.
I also think that HTS thins the mucus. My understanding is that it works by creating a saltier environment. Naturally through osmosis, water is then moved to the areas the HTS penetrated to dilute the salt, in effect thinning the mucus, making it move, tickle and invoking a coughing response. There can also be coughing due to irritation of course.
Anyways, that's the rationale as it was explained to me and IMHO it makes sense. You should bring up the question of the sequencing with your doctor. ~Juliet