<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Ender</b></i>
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>dramamama</b></i>
Just thought y'all would like to know that the azstreonam has arginine as one of its components. Arginine is the precursor to Nitric Oxide.....one of the most important inhibitors of bacteria in immune response....it is actually bacteriacidal in itself and is produced by the human lungs just not in cf.
That is ,ost likely why so many are experiencing such great results with it in cf!!!</end quote></div>
Hey,
This is interesting cause from what i read, the aztreonam being used in the clinical trials does not have arganine in it. It is the IV az that has the arganine. From what i read on the Stanford site, they think that the arganine can increase inflammation in the lungs of cfers. I found that contradictive to what i have read in the past that arganine could be a benefit to cf patients. I really have no idea.....
From the site:
"Aztreonam Lysinate for Inhalation.Drug formulation: lysine salt of aztreonam (Gilead) - No inhibition by CF sputum (vs 90% inactivation of Tobi by CF sputum) .Aztreonam formulation for iv use contains arginine and may increase airway inflammation - Arginine is a substrate of nitric oxide synthetase - Inhaled arginine may contribute to inflammation in CF patients .Formulated for airway tolerability - Sterile and preservative-free solution - Safe in preclinical toxicology studies - Safe and well tolerated in Phase I-III trials in healthy subjects and patients with CF"
I know they are also testing GSNO, which has the same affect of NO but has a much longer half life. So if the goal of that drug is to increase NO, wouldn't it be a good thing if the IV contains arganine. Like, what the hell?
$$?
Have they even tried IV AZ in cf patients? I'm curious....
Kiel</end quote></div>
Whoa Ender!!
Thanks for posting this!!! I had no idea they changed the formulation and was actually excited about the prospect of arginine....dang it! I actually inhaled Tobra long before Tobi and cannot inhale the Tobi version...the reformulation is too hard on me. One of the preservatives (phenol I think) was awesome in keeping my inflamation down....Tobi causes inflamation for me. And of course, phenol is HIGHLY antibacterial in and of itself....oand of course, it is not in TOBI.
Strange about the arginine...when I was trying to get a compounding pharmacy to mix arginine for me (buffered in its own salts) the pharmacist said that he had recently read that the reformualtion of azstreonam lacked arg because they believed it to be inflammatory. All evidence to the contrary in cf unfortunately....as arginine is so important in development of NO, smoothe muscle relaxation and of course in immune defense particularly in the lung.
Thanks for posting this...once again, if that is the case, why is there a clinical trial by the CFF with inhaled GSNO? Crazy.
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>dramamama</b></i>
Just thought y'all would like to know that the azstreonam has arginine as one of its components. Arginine is the precursor to Nitric Oxide.....one of the most important inhibitors of bacteria in immune response....it is actually bacteriacidal in itself and is produced by the human lungs just not in cf.
That is ,ost likely why so many are experiencing such great results with it in cf!!!</end quote></div>
Hey,
This is interesting cause from what i read, the aztreonam being used in the clinical trials does not have arganine in it. It is the IV az that has the arganine. From what i read on the Stanford site, they think that the arganine can increase inflammation in the lungs of cfers. I found that contradictive to what i have read in the past that arganine could be a benefit to cf patients. I really have no idea.....
From the site:
"Aztreonam Lysinate for Inhalation.Drug formulation: lysine salt of aztreonam (Gilead) - No inhibition by CF sputum (vs 90% inactivation of Tobi by CF sputum) .Aztreonam formulation for iv use contains arginine and may increase airway inflammation - Arginine is a substrate of nitric oxide synthetase - Inhaled arginine may contribute to inflammation in CF patients .Formulated for airway tolerability - Sterile and preservative-free solution - Safe in preclinical toxicology studies - Safe and well tolerated in Phase I-III trials in healthy subjects and patients with CF"
I know they are also testing GSNO, which has the same affect of NO but has a much longer half life. So if the goal of that drug is to increase NO, wouldn't it be a good thing if the IV contains arganine. Like, what the hell?
$$?
Have they even tried IV AZ in cf patients? I'm curious....
Kiel</end quote></div>
Whoa Ender!!
Thanks for posting this!!! I had no idea they changed the formulation and was actually excited about the prospect of arginine....dang it! I actually inhaled Tobra long before Tobi and cannot inhale the Tobi version...the reformulation is too hard on me. One of the preservatives (phenol I think) was awesome in keeping my inflamation down....Tobi causes inflamation for me. And of course, phenol is HIGHLY antibacterial in and of itself....oand of course, it is not in TOBI.
Strange about the arginine...when I was trying to get a compounding pharmacy to mix arginine for me (buffered in its own salts) the pharmacist said that he had recently read that the reformualtion of azstreonam lacked arg because they believed it to be inflammatory. All evidence to the contrary in cf unfortunately....as arginine is so important in development of NO, smoothe muscle relaxation and of course in immune defense particularly in the lung.
Thanks for posting this...once again, if that is the case, why is there a clinical trial by the CFF with inhaled GSNO? Crazy.