My son was in this trial and yes the 3 times a day treatments was a big pain in the *ss, on top of everything else, but I can tell a difference in his breathing (for the worse)since he has not been on it. Unfortunately he can not be in the new trial because they are not taking from the same pool of people. I dont care that the treatments took up so much time, I wish he could still be on it. I hope that when all is said and done they will determine that you only need to take once or twice a day and yes I have heard that this could replace H.S. as a treatment as well.