The drug is supposed to take 15 minutes, but I've found it takes closer to 20 minutes to finish it. Morning and before bed isn't bad, but that middle one is tough. I have a nebulizer compressor at work at I try to do it at 2pm every day, but some days I just get too busy and can't stop what I'm working on. Weekends are tough too because I like to sleep in. I'm lucky enough that I can still work 40 hours a week (usually more) but I'm usually pretty wiped out by the end of the week and I try to catch up on my sleep on Saturday. It makes it hard to get 3 treatments in, especially if I have a busy day planned once I get up.