Oh, since so many of you have mentioned hymoptysis. I would just say, Pulmozyme is definitely not the only reason for it. A couple years ago, I had several significant bleeds (2-4 oz at least). I went into the hospital where I had another big bleed. My doc put me on pulmozyme 3x a day for like a week. The bleeds stopped and I haven't had a major bleed since.