ME PERSONALLY I HAVE NEVER REFUSED THEM, I AM ONLY ON THEM ONCE OR TWICE A YEAR SO I JUST REALLY TAKE IT FOR GRANTED AND GO ON THEM, AT THE END OF THE IV'S I AM ALWAYS FEELING A LOT BETTER AND REALLY THINK IT WAS WORTH GOING ON THEM,.... ( MY PERSONALY OPINION) BUT I AM NOT SURE IF I WOULD EVER...